Continuous Glucose Monitor (CGM) Update – New Products Recently Released 

There have been some updates to the continuous glucose monitor (CGM) world since our last Newsline article released March 2024. Abbott has released two new sensors, FreeStyle Libre 2 Plus Sensor and FreeStyle Libre 3 Plus Sensor, that can be used with the FreeStyle Libre 2 Reader and FreeStyle Libre 3 Reader, respectively.

FreeStyle Libre 2 Plus Sensor became widely available around June 2024, followed by the FreeStyle Libre 3 Plus Sensor a few months later. The biggest difference introduced with both sensors is…

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they can be worn for up to 15 days and are indicated for children 2 years and older. FreeStyle Libre 2 Plus Sensors can also be integrated with insulin pumps while FreeStyle Libre 3 Plus Sensors work with Automated Insulin Delivery (AID) systems. For more information on the types of insulin pumps and AID systems, see the FreeStyle Libre website. As a reminder, FreeStyle Libre 2 Sensors and FreeStyle Libre 3 Sensors can only be worn up to 14 days and are indicated for children 4 years and older. These sensors cannot be integrated with insulin pumps or AID systems.

The chart below should be a helpful tool for referencing Dexcom and FreeStyle CGM products, NDCs, their respective NCPDP billing units, and corresponding days’ supply.

ProductNDCNCPDP Billing UnitReplacement Schedule
Dexcom G6 Receiver08627-0091-111 EachOnce a year
Dexcom G6 Transmitter08627-0016-011 EachEvery 3 months
Dexcom G6 Sensor08627-0053-033 EachEvery 30 days
    
Dexcom G7 Receiver08627-0078-011 EachOnce a year
Dexcom G7 Sensor08627-0077-011 EachEvery 10 days
    
FreeStyle Libre 14-day Sensor57599-0001-011 EachEvery 14 days
FreeStyle Libre 14-day Reader57599-0002-001 EachEvery 3 years
FreeStyle Libre Reader57599-0000-211 EachEvery 3 years
    
FreeStyle Libre 2 Sensor57599-0800-001 EachEvery 14 days
FreeStyle Libre 2 Plus Sensor57599-0835-001 EachEvery 15 days
FreeStyle Libre 2 Reader57599-0803-001 EachEvery 3 years
    
FreeStyle Libre 3 Sensor57599-0818-001 EachEvery 14 days
FreeStyle Libre 3 Plus Sensor57599-0844-001 EachEvery 15 days
FreeStyle Libre 3 Reader57599-0820-001 EachEvery 3 years

PAAS Tips:

  • See our March 2024 Newsline article, Continuous Glucose Monitor (CGM) Billing and Supply Allowance for additional Medicare Part B billing information
    • Use the CGM Supply Allowance Billing Calculator found on your DME MAC website to help determine when the next date of service can be billed
      • CGS
      • Noridian
    • Check out this similar tool myCGS for a complete claim history to be sure the patient has not received supplies from another supplier in the last 30 or 90 days
    • If the patient requires a replacement sensor, transmitter, or receiver due to a product failure, be sure to document and replace the item while reaching out to the manufacturer
  • The NCPDP billing units shown in the chart above would apply to non-Medicare Part B claims
  • Beware that any PBM, including Medicare Part B, will recoup or deny a claim if it is refilled too soon based on days’ supply guidelines above

Using and Documenting Priming Units on Insulin Pens

In 1985, the first insulin pen was invented – it gave patients a flexible way of self-administration and autonomy from burdensome vials and syringes. Today there are a multitude of insulin products available as FlexPen®, FlexTouch®, KwikPen®, and Solostar® pens that offer convenience and discretion for patients with diabetes.

The patient Instructions for Use, included with insulin pen boxes, direct patients to prime the pen needle prior to administering each dose. This is for many reasons, including removing any air between the pen itself and the pen needle, ensuring the pen is properly working, and ensuring the correct dose is administered. The usual, reliable adage has been 2 priming units per dose, but some insulin pens require three to five priming units!

PAAS National® created the Insulin Medication Chart that includes which insulin pens deviate from the standard two priming units:

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InsulinPriming Units
Humulin® R U-500 KwikPen® regular insulin human5
Toujeo® Solostar® 300 Unit/mL insulin glargine3
Toujeo® MAX Solostar® 300 Unit/mL insulin glargine4

PAAS Tips:

  • If your pharmacy uses priming units to calculate days’ supply, make sure to document on the hard copy for auditing purposes.
  • When documenting priming units for the atypical products in the chart above, be sure to indicate the priming unit volume that you are calculating with

Electronic Prescription Fraud

Most community pharmacy employees know the “red flags” to spot a fraudulent written prescription such as it “looks too good”, has irregular quantities and instructions, different color ink or handwriting, and doesn’t follow the typical medical shorthand.

Unfortunately, it is much harder to spot a fraudulent electronic prescription. The bad guys are now using sophisticated computer schemes to steal login credentials from prescribers and hijack electronic health record systems to initiate thousands of fraudulent e-prescriptions to pharmacies across the country within a short period of time. When these e-prescriptions are received at the pharmacy, the normal red flags are nowhere to be seen, and they may slip through undetected.

For these fraud schemes to pay off, the criminals must actually get their hands on the medications. Target medications are often not just controlled substances that can be sold on the street, but also expensive branded medications (dispensed in manufacturer stock bottles) that can be recirculated through an illegitimate supply chain. A Drug Topics article from April 2024 outlined these schemes including the use of “drug runners” to pick up medications from unsuspecting pharmacies.

Pharmacies need to be aware that the end-to-end electronic prescribing process, while generally secure, does have the potential to be exploited by criminals. It is important that both pharmacy technicians and pharmacists play a role to protect the integrity of this process. Pharmacies should consider some basic strategies to determine authenticity of e-prescriptions to ensure your pharmacy isn’t pulled unwittingly into a fraud scheme.

Below are some techniques to spot fraudulent electronic prescriptions at your pharmacy:

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  1. Know the prescriber
    1. Is this a new prescriber in your area?
    2. Have you received electronic prescriptions from this prescriber before?
    3. Is the medication within their scope of practice?
    4. Can you verify prescriber information (e.g. phone, address) through public resources?
    5. Check your state PDMP for any controlled substance prescriptions that don’t add up.
  2. Know the patient/caregiver
    1. Is this a new patient at your pharmacy?
    2. Does this patient live within your service area?
    3. How did you obtain the third-party billing information?
    4. Consider requiring a copy of photo identification for prescriptions picked up for new patients
    5. Large cash copays paid by a representative unknown to pharmacy may be a clue that they are trying to avoid detection
    6. Some level of skepticism, if all interactions are with a personal representative
  3. Review the prescription for unusual items such as:
    1. Is dose regimen outside the norm?
    2. Does patient have indication to support use?
    3. Does the patient have other prescriptions from this prescriber? Can the patient confirm they are being treated by the prescriber?
    4. Are there multiple prescriptions issued for high-cost medications brand medications, particularly those that may be dispensed in their original, intact containers?

With fraudulent electronic prescriptions being on the rise, pharmacies should consider formulating a business policy to handle these situations. A key first step is conducting due diligence before concluding that a prescription is fraudulent. When validating with a prescriber, the pharmacy should request documentation [preferably in writing] that the prescription is fraudulent. If the prescription was billed to insurance and later reversed due to a determination of it being a fraudulent prescription, the hardcopy should still be retained in case of an audit. The prescriber should take the lead on notifying authorities and researching their stolen credentials, but pharmacies may have a corresponding responsibility to notify the state board of pharmacy and/or DEA (especially when prescriptions were dispensed). FWAC Members can utilize the custom content section of their Policy and Procedure Manual to create and upload a fraudulent prescription policy.

If a prescription is dispensed and later identified as fraudulent, pharmacies are obligated to reverse the claims and likely notify the third-party payor. During a PBM audit, fraudulent electronic prescriptions will be subject to financial recoupment and the onus will be on the pharmacy to prove that they were ‘duped’ as well and not in on the fraudulent activity.

PAAS Tips:

  • DEA has a brief video about fraudulent e-prescriptions and a handout on general prescription fraud here
  • When prescriptions are identified as fraudulent, document your due diligence efforts on the prescription or in your pharmacy management software

Tennessee Pharmacist Conducts Multi-Million Dollar Health Care Fraud Scheme

In December 2024, a Tennessee pharmacist was arrested and charged with nine counts of Health Care Fraud and six counts of Aggravated Identity Theft for operating a health care fraud scheme that resulted in over $6 million worth of false claims being submitted to several insurers.

A federal indictment returned in late December revealed that a Tennessee pharmacist who oversaw a pharmacy with several locations in Tennessee, had been submitting false claims to Medicare, Medicaid, TRICARE, and Blue Cross Blue Shield for prescription drugs that were deemed not medically necessary, were not actually dispensed to a patient, or had no evidence of being ordered by a health care provider. In many instances, the pharmacist would use the identification of other people, without their consent, to receive reimbursement for claims submitted to a health care benefit program. The pharmacies profited from these schemes by receiving fraudulent reimbursement for personal use.

The case is being investigated by the U.S. Department of Health and Human Services, Office of Inspector General, the Tennessee Bureau of Investigation, and the Department of Defense, Office of Inspector General. If convicted, the pharmacist will face up to ten years in federal prison for each count of health care fraud, and two consecutive years in federal prison for the aggravated identity theft counts. The U.S. is also seeking a money judgement of $6,524,585.44, which represents the proceeds of the fraud scheme.

PAAS Tips:

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  • Only bill a claim pursuant to a valid prescription on file. Billing a “test” claim or “ghost” claim is prohibited by PBMs and those claims, even if reversed, are subject to audit.
    • Failure to provide a valid hardcopy can raise red flags and lead to accusations of billing false claims

Why PBMs Insist on Understanding Dispense Quantity Changes

When a pharmacy dispenses a quantity other than what was prescribed, it requires documentation. PBMs will want to know the rationale, whether the quantity was increased or decreased. There are plenty of valid reasons a pharmacy may need to change the quantity, including …

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patient requests, insurance limitations, med sync programs, or dispensing in the original container per manufacturer guidelines. Some reasons that are NOT valid include working around negative reimbursement rates, trying to collect more dispensing fees, or circumventing plan limitations. Many PBMs have a discrepancy code for lack of proper documentation to support these changes, making full recoupment possible.

Contractual obligations apply when filling prescriptions and should be considered when adjusting quantities. Opting out of extended days’ supply networks when/where possible may help alleviate some negatively reimbursed claims while still adhering to the agreement. If PBMs are notified of a pharmacy refusing to dispense a 90 days’ supply (while being contracted for extended days’ supply networks), they may issue a cease and desist letter that can result in required corrective action plans or even network termination if not corrected. One PBM in particular has language in their agreement that allows them to extend 90 days’ supply pricing to 30 days’ supply claims if the pharmacy is found to disproportionately dispense 30-day fills in comparison to peers.

Increasing the quantity dispensed requires a different set of considerations. Check your state law on whether you are allowed to increase the quantity without consulting the prescriber (i.e., accelerated refills). If so, document accordingly and ensure you are not dispensing more than the total quantity authorized on the prescription. If not allowed, contact the prescriber for approval and document a clinical note.

When a prescriber orders a quantity that is less than the smallest package size, contact the prescriber for approval to dispense a total quantity larger than originally prescribed and document a clinical note. For example, if NovoLog FlexPen® was prescribed for a written quantity of 3 mL with 2 refills, the total quantity on the prescription is only 9 mL. The pharmacy should call the prescriber to clarify the quantity and refills (to comply with FDA labeling requirements and dispense a full box of 15 mL). It’s important to include what the new quantity prescribed AND refills are to avoid any ambiguity on what the total quantity approved on the prescription is (e.g., prescriber approved increasing quantity to 15 mL with two additional refills).

PAAS Tips:

  • Always document the reason for any quantity change
  • Check your state law before increasing the quantity without prescriber approval
  • Be careful not to dispense more than was authorized on the prescription
  • Verify quantity and refills with prescriber if quantity prescribed is less than a package size
  • Do not change the quantity due to negative reimbursement, additional dispensing fees or working around plan limitations
  • Clinical notes should contain four elements:
    • Date
    • Name and title of who you spoke with
    • What was discussed
    • Your initials

Keeping the Diagnoses Straight for GLP-1 Products

The FDA recently announced that Zepbound® (tirzepatide) has been approved for the treatment of moderate to severe obstructive sleep apnea (OSA) in adults with obesity. This is the first GLP-1 indicated for OSA. The popularity of GLP-1 products has not slowed down, but with the new diagnosis for Zepbound® it is a good time to review the GLP-1 products and their FDA-approved diagnoses. 

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Many PBMs DO NOT require a diagnosis code to be on the prescription or to submit the diagnosis code at the time of adjudication. However, it is important that the correct product is being dispensed for the proper diagnosis.

In the December 2023 Newsline, Zepbound® (tirzepatide) Means Decreased Audit Risk…Right?, off-label uses of GLP-1 products were discussed. Medicare part D plans require that drugs are prescribed for medically accepted indications. Other PBMs have language in the Provider Manuals that define “clean claims” as one that is used for a medically accepted indication or outlines “appropriate dispensing practices”.  The chart below summarizes the current diagnoses for the approved GLP-1 products.

GLP-1 generic nameGLP-1 brand nameApproved indication(s)
LiraglutideVictoza®Type 2 diabetes in adults and children 10 years or olderType 2 diabetes in adults with known heart disease
Saxenda®Weight loss in adults and children 12 years or older
 
DulaglutideTrulicity®Type 2 diabetes in adults and children 10 years or olderReduce cardiovascular events in adults with type 2 diabetes with established cardiovascular disease or multiple risk factors
 
SemaglutideOzempic®Improve glucose in adults with type 2 diabetesReduce risk of cardiovascular events in adults with type 2 diabetes with known heart disease
Wegovy®Reduce risk of cardiovascular events in adults with type 2 diabetes with known heart disease AND either obesity or overweightAdults and children 12 and older with obesityOverweight adults who have weight-related medical problems
 
TirzepatideMounjaro®Adults with type 2 diabetes to improve blood sugar
Zepbound®Moderate-to-severe obstructive sleep apnea in adults with obesityObesity in adultsOverweight adults who have at least 1 weight-related comorbid condition

PAAS Tips:

Top Ten Newsline Articles for 2024

In today’s fast-paced world, it’s crucial to stay informed with the latest insights to avoid putting your pharmacy at risk. For all pharmacy staff, continuous education is key. Mailed to pharmacies with the January Newsline, this article reviews the top ten PAAS National® Newsline articles from 2024 that were the most read tips and trends to help be proactive in preventing audits.

  1. Be Conscientious When Refusing to Dispense (or Bill Insurance)…
  2. Insulin Substitution Review: Understanding Purple Book Terminology
  3. PBM Audits on Ozempic®: 5 Common Discrepancies Revealed
  4. New Dispense As Written (DAW) Code Revealed
  5. OptumRx Continues to Cause Headaches!
  6. Best Practices for DAW Billing in Pharmacies
  7. Continuous Glucose Monitor (CGM) Billing and Supply Allowance
  8. Major PBMs Announce “Cost Plus” Pharmacy Networks
  9. OptumRx Targeting Medications Requiring Dispensing in Original Containers
  10. Commercial Claims Reimbursed Through Embedded GoodRx® Discount Cards

In addition, below are the top articles that are available only on the Member Portal.

  1. Days’ Supply Considerations for Eye Medications
  2. Required: Proof of Patient Copay Collection
  3. Painful Lessons: What You Should Know About Return to Stock Timeframes
  4. Transfer Tragedy: A Timeworn PBM Target
  5. Addressing “Weird” Days’ Supply
  6. Metformin HCL ER – Audit Considerations
  7. Pharmacy Owner’s Involvement in Fraud Scheme Leads to 4-Year Prison Sentence

When using the PAAS eNewsline on the Member Portal, you are able to search the Newsline Archive via keyword. Let the knowledge from these articles fuel your journey toward improved operations and a more engaged pharmacy staff.

Access these popular articles via the links above or you can print the Top 10 Articles of 2024 resource for a quick read.

Unique Eyedrop Calculation Challenges

Pharmacy social media platforms host passionate discussions on the correct way to bill days’ supply for eyedrops almost every week. Do you use 15 drops/mL, 20 drops/mL, or something else? As it turns out, the “right answer”  depends on the PBM you are billing and if the eyedrop is a solution or a suspension. Sound complicated? PAAS National® has a one-page chart and an app for that!

To make matters worse, there are some unique situations where using the PBM guidance is not relevant.

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For example, some manufacturers have specific guidance for drops/mL due to a viscosity and drop size difference (e.g., Miebo® [272 drops/3 mL], Vevye® [200 drops/2 mL], and Vyzulta® [81 drops/2.5 mL]), and you should calculate the days’ supply based on the manufacturers’ guidance.

Additionally, some eyedrops have a specific beyond use date in Section 16 Storage and Handling of the product labeling (e.g., AzaSite® [14 days], Rocklatan® [42 days], Rhopressa® [42 days], Vyzulta® [56 days], Xalatan® [42 days]) and cannot have a days’ supply greater than the beyond use date. Do not assume that all eyedrops have a beyond use date of 28 days. This is NOT true in most cases.

If a prescriber indicates that patient should discard the eyedrop after using it for ’X’ number of days, this must be explicitly spelled out in the directions to the patient. For example, eye drops that are to be used in the right eye for two weeks after surgery then discarded for a new bottle to be used for the left eye should clearly indicate this in the directions before billing a 14-day supply. If multiple package sizes of the product exist, use the smallest bottle closest to the treatment duration as possible. The PBM will not pay for a patient to discard the remainder of a 15 mL bottle when a 5 mL bottle would have sufficed.

PAAS Tips:

  • There is no industry accepted conversion for Gel or Ointment products
  • Follow the individual PBM published guidelines when billing days’ supply
  • OptumRx is the only PBM the explicitly states you may use treatment duration (e.g., “Use for ten days”) as the days’ supply
  • The quantity prescribed should contain a unit of measure that corresponds to the billing unit; however, if written for a quantity of “1 bottle”, it should be interpreted as the smallest package size
  • Login to the Member Portal under “Days’ Supply Charts” to find the most current version of PAAS’ Eye Drop Chart with major PBM drops per mL ratios
  • Download the PAAS National® Rx Days’ Supply Calculator from the App Store or Google Play
  • Review the November 2024 article, 2024 Self-Audit Series #9: Eye Drop Days’ Supply for additional guidance

Best Practices for Out-of-Stock Medications

PAAS National® analysts continue to see pharmacies struggle with invoice audits, which are most frequently performed by Caremark® and OptumRx®.

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Most PBMs perform invoice audits on an aggregated basis and total all claims billed to their particular PBM over an entire date range (e.g. 12 months). The totals of each NDC billed are then compared against the pharmacy’s purchases from authorized wholesalers over a similar period. If a pharmacy has an “inventory shortage”, it is commonly explained by a missing wholesaler purchase file, wrong NDC billed, purchases from an unauthorized wholesaler, or even product on the shelf prior to the date range.

Occasionally, pharmacies have shortages due to a claim being billed at the end of an audit date range for a medication that the pharmacy has not ordered/stocked before. If this out-of-stock claim falls inside the audit date range but the date of invoice falls outside (after) the date range, this can create a mathematical shortage. These situations are generally rare but can create issues for pharmacies undergoing an invoice audit.

Most PBMs have language that states the date of service must reflect the date the prescription is “prepared/readied for dispensing”, which they can argue isn’t possible without the drug on-hand. OptumRx, Horizon NJ Health, and NJ Medicaid take the language in their Provider Manuals (or Agreements) even further, indicating that pharmacies are required to have product in stock prior to even submitting a claim for the drug product. This requirement is highly impractical as pharmacies cannot afford to stock every medication that exists and do not know if a prescribed medication is even covered (or if patient even wants it) until after the claim is billed. Pharmacies should consider reversing claims for high cost, out-of-stock medications and rebilling them after the product has been ordered and is on-hand to reduce audit liability.

PAAS Tips:

If you’re not a member of PAAS’ FWA/HIPAA compliance program, contact us today at (608) 873-1342 or info@paasnational.com to add the program for a discounted rate.

Oral-Only ESRD Drugs Removed from Medicare Part D Coverage in 2025

Starting January 1, 2025, Medicare Part D no longer covers “oral-only” medications used for patients with end-stage renal disease (ESRD) undergoing dialysis treatment. This mainly impacts payment of phosphate binders such as PhosLo® (calcium acetate) and Renvela® (sevelamer carbonate), as well as Xphozah® (tenapor).

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When used for ESRD patients, these oral-only medications will now be covered by Medicare Part B under the ESRD Prospective Payment System (PPS) bundled payment to dialysis facilities and should NOT be billed by pharmacies to a Medicare patient’s Part D plan (pharmacies will also not be able to bill Medicare B). If pharmacies are looking to continuing dispensing these medications, advanced coordination with dialysis facilities will be required to ensure pharmacies receive reimbursement.

Part D claims may reject with the following NCPDP reject codes:

  • 75>Prior Authorization Required
  • 569>Provide Notice: Medicare Prescription Drug Coverage and Your Rights
  • A4>This product may be covered under the Medicare-B Bundled Payment to an ESRD Dialysis Facility

If Part D claims do not reject and pharmacy bills Part D incorrectly, then there will likely be future coordination of benefit (COB) “audits” where the Part D plan recoups the pharmacy payment, leaving the pharmacy to reconcile with the dialysis facility after the fact. PAAS National® already sees these types of retroactive, COB audits when claims were billed to Part D but “should have” been billed to Part A for patients residing in a nursing home on a covered stay.

Phosphate binders remain coverable under Part D for other medically accepted indications for patients not on dialysis for ESRD. Pharmacies may want to obtain (and document) diagnosis codes to support these claims.

Numerous organizations, including NCPA, the American Society of Consultant Pharmacists (ASCP), and the American Society of Nephrology (ASN) provided feedback to CMS that this change in payment policy will negatively affect patients as many dialysis facilities do not have an in-house pharmacy and may supply these medications without the expertise of a pharmacist.

PAAS Tips:

  • Educate billing staff about the likely rejects for phosphate binder medications for Part D patients
  • Coordinate with dialysis facilities to ensure continuity of patient care and payment for pharmacy services