Eye Drop Guidance Updates: Prime Therapeutics

Old Guidance: “Calculate eye drops days’ supply using 15 drops per mL for solutions and 12 drops per mL for suspensions.”

New Guidance: “Calculate eye drops days’ supply based on the specific product.”

This guidance is challenging, as there is no master list of eye drop medications where the drop/mL information is specified by the manufacturer. New eye drops are coming to market that are free of water and preservatives; consequently, the drop size is approximately 66% – 80% less than traditional eye drops (see example list below).  Absent this information, PAAS National^® suggests that pharmacies use 20 drops per mL for solutions and 15 drops per mL for suspensions when products do not specify drops/mL.

Manufacturer Specific Drop per mL:

1. Miebo^® 272 drops per 3 mL (~90 drop per mL)
2. Vevye^® 200 drops per 2 mL (100 drop per mL)
3. Vyzulta^® 81 drops per 2.5 mL (~32 drop per mL)

PAAS Tips:

• Download the most current Eye Drop Days’ Supply Chart located on the Member Portal under “Days Supply Charts”
• Review the February 2025 Newsline article Unique Eyedrop Calculation Challenges and our November 2024 Self-Audit Series #9: Eye Drop Days’ Supply for additional tips on billing eye drops
• Consider using the PAAS National^® Rx Days’ Supply Calculator for iOS or Android