Best Practices When Filling & Billing Afrezza®

Afrezza®, a rapid-acting insulin human inhalation powder for adults with either type 1 or type 2 diabetes mellitus, can cause confusion for prescribers, pharmacies, and patients alike.

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Fortunately, the Afrezza® website has numerous tools and resources that can assist in proper filling and billing practices.

  • Prior Authorization Checklist – provides pharmacies and prescribers a clear and concise list of information to be submitted to insurance when requesting a prior authorization.
  • Product Reference Guide – a compilation of NDC’s for both combination and single box options. In addition, the guide gives total insulin units, total cartridges, and max total daily dose which can be used when determining how many boxes to dispense to satisfy a 30 days’ supply.
  • Afrezza Dosing Calculator – a tool that can be used to assist pharmacies in choosing the most appropriate NDC to use to fill the prescription

Afrezza® is only available in specific unit cartridges – 4 units, 8 units, and 12 units. In instances where a patient requires a dose greater than 12 units, the patient will need to use additional cartridges to obtain the correct dose. Prior to filling the prescription, ensure the dose prescribed for the patient is obtainable. If the dose is not feasible, the prescription is at a high risk of recoupment on audit.

Meredith Thiede, PharmD